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| Reactivity: | M,R & H,M,R |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Fos B rabbit polyclonal antibody |
Gene Name: | Protein fosB |
Synonyms: | FOSB, AP-1, G0S3, GOS3, GOSB, FosB, ΔFosB, FosB proto-oncogene, AP-1 transcription factor subunit |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FOSB |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 36 kDa |
Observed MW. | 36 kDa |
Uniprot ID: | P53539, P13346 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | liver cancer |
Background
The FOS gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipperproteins that can dimerize with proteins of the JUN family (e.g., c-Jun, JunD), thereby forming thetranscription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. FosB and its truncated splice variants, ΔFosB and further truncated Δ2ΔFosB, are all involved in osteosclerosis, although Δ2ΔFosB lacks a knowntransactivation domain, in turn preventing it from affecting transcription through the AP-1 complex.
Images
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Western blot analysis of FOSB (GB11270) at dilution of 1: 500 |
| Western blot analysis of FOSB (GB11270) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
