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Anti-G-CSF Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | G-CSF rabbit polyclonal antibody |
Gene Name: | Granulocyte colony-stimulating factor |
Synonyms: | G-CSF, Csf3, Csfg, CSF3, GCSA |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse G-CSF |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 22 kDa |
Observed MW. | 19 kDa |
Uniprot ID: | P09920, P97712 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 800 | kidney, lung, liver |
Background
Granulocyte colony-stimulating factor (G-CSF), also referred to as CSF3, is a protective cytokine with anti-inflammatory effects. G-CSF is important in promoting survival of the granulocytic lineage cells and proliferation and migration of neutrophils as well as trophoblast cells. G-CSF acts by binding to its receptor G-CSFR (also called CSF3R), which after binding with G-CSF activates the canonical Janus kinase (Jak)/signal transducer, activator of transcription (STAT)and Ras/Raf/MAP kinase pathways. G-CSF potently stimulates the proliferation and release of peripheral blood progenitor cells into the bloodstream and is therefore used to treat neutropenia after chemotherapy. Furthermore, G-CSF levels are elevated upon intensive exercise leading to increased neutrophil counts, which are predominantly due to delayed neutrophil apoptosis.
Images
| Western blot analysis of G-CSF (GB111039) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
