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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GAD1 rabbit polyclonal antibody |
Gene Name: | Glutamate decarboxylase 1 |
Synonyms: | Gad1, GAD1, CPSQ1, GAD, SCP, glutamate decarboxylase 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GAD1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 67 kDa |
Observed MW. | 67 kDa |
Uniprot ID: | P48318, P18088 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, cerebral cortex, cerebellum |
Background
Glutamate decarboxylase 1 (brain, 67kDa) (GAD67), also known as GAD1, is one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. This enzyme is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures.
Images
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Western blot analysis of GAD67 (GB11717) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
