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| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GBA rabbit polyclonal |
Gene Name: | Lysosomal acid glucosylceramidase |
Synonyms: | GBA, GBA1, GCB, GLUC, Glucosylceramidase beta, Glucocerebrosidase, BETA GLUCOSIDASE, ACID, Gba protein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GBA |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: |
Images
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1000-1: 2000 | kidney, stomach, small intestine, fetal rat |
IF | Mouse, Rat | 1: 500-1: 1000 | kidney, stomach, small intestine, fetal rat |
Background
The GBA is a glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes . Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism . May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol . The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol .
Images
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using GBA (GB111110) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat kidney using GBA (GB111110) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse stomach using GBA (GB111110) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat small intestine using GBA (GB111110) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse fetal rat using GBA (GB111110) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
