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Anti-G protein beta subunit like/GBL Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | G protein beta subunit like/GBL rabbit polyclonal antibody |
Gene Name: | Target of rapamycin complex subunit LST8 |
Synonyms: | TORC subunit LST8, G protein beta subunit-like, Protein GbetaL, Mammalian lethal with SEC13 protein 8, mLST8, Gbl, Lst8, MGC111011 |
Immunogen: | Recombinantproteincorresponding to Mouse G protein beta subunit like/GBL |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: | Q9BVC4, Q9DCJ1 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse | 1: 600-1: 1300 | lung cancer |
Background
G-protein beta subunit like (GBL protein) is a novel member of WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of mTOR signaling complex (TORC1) and positively up-regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor. LST8 participates in regulating cell growth and also in nutrient and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin indicating a possible role of LST8 in intracellular events related to insulin-receptor activation including insulin-stimulated glucose transport and glycogen synthesis.
Images
 | Immunohistochemistry of paraffin embedded human lung cancer using LST8 (GB111687) at dilution of 1:650 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
