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Anti-GFI1B Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Zinc finger protein Gfi-1b |
Synonyms: | Growth factor independent protein 1B, Gfi1b, Translocated in CML, Potential regulator of CDKN1A translocated in CML, GFI1B protein |
Immunogen: | Recombinant protein corresponding to Mouse GFI1B |
Uniprot ID: | O70237 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 37 kDa / 37 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | Jurkat, K562, Raji |
Background
GFI1b (zinc finger protein GFI-1b) is an essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. It is also a component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. GFI1b also acts as a transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways.
Images
| Western blot analysis of GFI1B (GB111819) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
