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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Gamma-interferon-inducible lysosomal thiol reductase |
Synonyms: | GILT, IFI 30, IFI30, IP30 |
Immunogen: | Recombinant protein corresponding to Mouse GILT |
Uniprot ID: | Q9ESY9 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted, Lysosome |
Product Usage Information
IHC/IF | Human | 1: 1500-1: 3000 | liver, placenta |
Background
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation.
Images
| Immunohistochemistry analysis of paraffin embedded human liver using GILT (GB114228) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin embedded human placenta using GILT (GB114228) at dilution of 1: 3000 |
| Immunofluorescence analysis of paraffin embedded human pplacenta using GILT (GB114228) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
