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Anti-Glucose Transporter GLUT4 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Glucose Transporter GLUT4 antibody |
Gene Name: | Solute carrier family 2, facilitated glucose transporter member 4 |
Synonyms: | SLC2A4, GLUT4, solute carrier family 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GLUT4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Endomembrane system |
Uniprot ID: | P14142, P19357 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 400-1: 1600 | heart, Skeletal muscle |
Background
At the cell surface, GLUT4 permits the facilitated diffusion of circulating glucose down its concentration gradient into muscle and fat cells. Once within cells, glucose is rapidly phosphorylated by glucokinase in the liver and hexokinase in other tissues to form glucose-6-phosphate, which then enters glycolysis or is polymerized into glycogen. Glucose-6-phosphate cannot diffuse back out of cells, which also serves to maintain the concentration gradient for glucose to passively enter cells.
Images
| Immunohistochemistry of paraffin embedded mouse skeletal muscle using Glut4 (GB11244) at dilution of 1:800 (400x lens) |
| Immunohistochemistry of paraffin embedded rat heart using Glut4 (GB11244) at dilution of 1:800 (400x lens) |
| Immunohistochemistry of paraffin embedded rat skeletal muscle using Glut4 (GB11244) at dilution of 1:800 (400x lens) |
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Immunofluorescence of paraffin embedded mouse heart using glut4 (GB11244) at dilution of 1:400 (400x lens) |
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Immunofluorescence of paraffin embedded rat heart using glut4 (GB11244) at dilution of 1:400 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
