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Anti-GPCR GPR40 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Free fatty acid receptor 1 |
Synonyms: | G-protein coupled receptor 40, Ffar1, Gpr40 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GPCR GPR40 |
Uniprot ID: | Q76JU9 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 32 kDa / 32 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | brain, pancreas, uterine |
IHC/IF | Mouse, Rat | 1: 650-1: 1300 | corpus striatum, spinal cord, substantia nigra |
Background
G protein-coupled receptor 40 (GPR40) functions as a cell-surface receptor for long-chain free fatty acids (FFAs). FFAs provide an important energy source, but also function as signaling molecules in various pathways, notably the process of insulin secretion. In pancreatic tissue, the interaction of long chain FFAs with GPR40 amplifies glucose-stimulated insulin secretion from beta cells, suggesting a possible role for GPR40 in the treatment of diabetes associated with insulin-deficiency. Specifically, the Arg211His polymorphism in the GPR40 gene may contribute to the variation of insulin secretory capacity in Japanese men.
Images
| Western blot analysis of GPR40 (GB112137) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraffin embedded rat substantia nigra using GPR40 (GB112137) at dilution of 1: 650 |
| Immunofluorescent analysis of paraffin embedded rat spinal cord using GPR40 (GB112137) at dilution of 1: 650 |
| Immunofluorescent analysis of paraffin embedded mouse corpus striatum using GPR40 (GB112137) at dilution of 1: 650 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
