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Anti-GRP94 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GRP94 rabbit polyclonal antibody |
Gene Name: | Endoplasmin |
Synonyms: | 94 kDa glucose-regulated protein, GRP-94, ERp99, Heat shock protein 90 kDa beta member 1, Polymorphic tumor rejection antigen 1, Tumor rejection antigen gp96, Hsp90b1, GRP94, Tra-1, Tra1 |
Immunogen: | Recombinant protein corresponding to Mouse GRP94 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 92 kDa |
Observed MW. | 100 kDa |
Uniprot ID: | P14625, P08113, Q66HD0 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung, brain |
Background
GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family. It acts as a molecular chaperone that functions in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulates CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, cross-priming, as a potential marker in breast cancer and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. GRP94 is expressed in melanoma or liver metastases of colon carcinoma cells, human gastric carcinoma BGC-823 cells.
Images
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Western blot analysis of GRP94 (GB111280) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
