Reactivity: | H |
Applications: | IHC/IF |
Host Species: | Mouse |
Clonality: | Monoclonal |
Gene Name: | Galectin-3 |
Synonyms: | LGALS3, CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2, lectin, galactoside binding soluble 3, galectin 3 |
Immunogen: | Recombinant protein corresponding to Mouse Galectin 3 |
Uniprot ID: | P16110 |
Isotype: | IgG2a,κ |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm,Secreted,Nucleus |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1: 500-1: 2000 | amygdalitis, colon, colon cancer |
Background
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.
Images
Immunohistochemistry of paraffin embedded human amygdalitis using MAC-2 (GB12246) at dilution of 1: 1000 (400x lens) |
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Immunohistochemistry of paraffin embedded human colon cancer using MAC-2 (GB12246) at dilution of 1: 1000 (400x lens) | |
Immunohistochemistry of paraffin embedded human colon using MAC-2 (GB12246) at dilution of 1: 1000 (400x lens) |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |