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Anti-Gemin 2 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Gem-associated protein 2 |
Synonyms: | Gemin2, GEMIN2, SIP1, SIP1-delta, Survival of motor neuron protein-interacting protein 1, gem nuclear organelle associated protein 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Gemin 2 |
Uniprot ID: | Q9CQQ4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 30 kDa / 30 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | skeletal muscle, testis |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | testis |
Background
This gene encodes one of the proteins found in the SMN complex, which consists of several gemini proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Images
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Western blot analysis of SIP1 (GB11862) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin embedded rat testis using SIP1 (GB11862) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
