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Anti-Glutamine Synthetase Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Glutamine synthetase |
Synonyms: | cell proliferation-inducing protein 59, GLNA, GLNS, GLUL, Glutamate ammonia ligase, Glutamate decarboxylase, Glutamine synthetase, GS, PIG43, PIG59, Proliferation inducing protein 43, Palmitoyltransferase GLUL |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Glutamine Synthetase |
Uniprot ID: | P15105 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 42 kDa / 42 kDa |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1500 | liver, lung, kidney |
Background
Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture.
Images
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Western blot analysis of Glutamune synthetase (GB11736) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
