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Anti-Granzyme K Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Granzyme K |
Synonyms: | Gzmk, Fragmentin3, NK-tryptase-2, Serine protease granzyme 3, TRYP2, TryptaseII, NK TRYP2 |
Immunogen: | Recombinant protein corresponding to Mouse Granzyme K |
Uniprot ID: | O35205 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasmic granule |
Predicted MW. / Observed MW. | 29 kDa / 29 kDa |
Product Usage Information
WB | Mouse, Rat | 1:500-1:1000 | spleen, liver, appendix |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1000 | tonsil, hippocampus |
Background
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.
Images
| Western blot analysis of Granzyme K (GB112190) at dilution of 1: 1000 |
| Immunofluorescence analysis of paraffin embedded human tonsil using Granzymek (GB112190) at dilution of 1: 500 |
| Immunofluorescence analysis of paraffin embedded mouse hippocampus using Granzymek (GB112190) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
