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Anti-H Cadherin Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | H Cadherin rabbit polyclonal antibody |
Gene Name: | Cadherin-13 |
Synonyms: | Heart cadherin, Truncated cadherin, T-cad, T-cadherin, CDH13, CDHH, P105 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse H Cadherin |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 78 kDa |
Observed MW. | 78 kDa |
Uniprot ID: | P55290, Q9WTR5, Q8R490 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500- 1: 1000 | cortex, spinal cord, heart |
Background
Cadherin13 is a member of the cadherin family of transmembrane glycoproteins that mediate calcium-dependent intercellular adhesion. However, Cadherin13 is an atypical member, lacking transmembrane and cytosolic domains and containing a GPI moiety that anchors Cadherin13 to the plasma membrane . Human Cadherin13 is synthesized as a 713 amino acid precursor that contains a 22 aa signal sequence, a 116aa propeptide, a 555aa mature chain, and a second propeptide of 20aa that is removed in the mature form to reveal the GPI anchor. The mature form contains five cadherin domains and eight potential sites for N-linked glycosylation. The structural characteristics of Cadherin13 predict that it is unlikely to function as a true adhesion molecule in vivo . It is suggested that it may act rather as a signaling receptor participating in recognition of the environment and regulation of cell motility, proliferation, and phenotype .
Images
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Western blot analysis of H-Cadherin (GB11996) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
