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Anti-HDAC4 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Histone deacetylase 4 |
Synonyms: | HA6116, HD4, HDAC A, HDAC4, HDACA, histone deacetylase 4, KIAA0288 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HDAC4 |
Uniprot ID: | Q6NZM9 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 119 kDa / 140 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 500 | brain, lung |
Background
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
Images
| WB analysis of HDAC4 (GB115512). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
