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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Transcription factor HES-3 |
Synonyms: | Hairy and enhancer of split 3, Hes3 |
Immunogen: | Recombinant protein corresponding to Mouse HES3 |
Uniprot ID: | Q61657 |
Isotype: | IgG2a,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 600-1: 1200 | embryonic mouse, embryonic rat, liver cancer |
Background
The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. HES3 is a member of the homeobox family of transcription factors. HES3 is expressed in undifferentiated embryonic stem (ES) cells and is also a target of the ES cell-specific network of transcription factors.
Images
| Immunohistochemistry of paraffin embedded human liver cancer using HES3 (GB121219) at dilution of 1: 600 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse embryonic mouse using HES3 (GB121219) at dilution of 1: 600 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse neonatal mouse's brain using HES3 (GB121219) at dilution of 1: 600 (400x lens) |
| Immunohistochemistry of paraffin embedded rat embryonic rat using HES3 (GB121219) at dilution of 1: 600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
