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Anti-HIF-2-alpha Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HIF-2-alpha rabbit polyclonal |
Gene Name: | Endothelial PAS domain-containing protein 1 |
Synonyms: | Epas1, EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, Endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha, HIF2α |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HIF2α |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 500-1: 1000 | lung, lung cancer |
IF | Mouse, Rat | 1: 250-1: 500 | lung, lung cancer |
Background
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Images
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Immunohistochemistry analysis of paraffin-embedded human lung cancer using HIF2α(GB11864) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse lung using HIF2α(GB11864) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
