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Anti-HMGCR Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HMGCR rabbit polyclonal antibody |
Gene Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Synonyms: | HMG-CoA reductase, Hmgcr, 3 hydroxy 3 methylglutaryl CoA reductase, 3H3M, HMG CoA, HMG CoAR, HMG-CoA reductase, LDLCQ3 |
Immunogen: | Recombinant protein corresponding to Mouse HMGCR |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: | Q01237, P51639 |
Applications
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 1000-1: 3000 | kidney, spinal cord, testis |
Background
HMGCR(3-hydroxy-3-methylglutaryl-coenzyme A reductase) is also named as HMG-CoA reductase and belongs to the HMG-CoA reductase family.HMGCR is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Images
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Immunohistochemistry of paraffin embedded mouse kidney using HMGCR (GB111352) at dilution of 1:1300 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse spinal cord using HMGCR (GB111352) at dilution of 1:1300 (400x lens) |
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Immunohistochemistry of paraffin embedded rat testis using HMGCR (GB111352) at dilution of 1:1300 (300x lens) |
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Immunohistochemistry of paraffin embedded rat kidney using HMGCR (GB111352) at dilution of 1:1300 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
