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Anti-HSD11B1 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HSD11B1 rabbit polyclonal antibody |
Gene Name: | Corticosteroid 11-beta-dehydrogenase isozyme 1 |
Synonyms: | 11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11-beta-HSD1, 11beta-HSD1A, Hsd11b1, Hsd11 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HSD11B1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 32 kDa |
Observed MW. | 32 kDa |
Uniprot ID: | P50172 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse | 1: 1000-1: 2000 | liver, kidney, testis |
Background
HSD11B1(Corticosteroid 11-beta-dehydrogenase isozyme 1) is also named as HSD11, HSD11L,11-DH and 11-beta-HSD1.It is a microsomal enzyme, which acts mainly as a NADP(H)- dependent reductase converting inactive cortisone (E) to active cortisol (F), thus regulating intracellular F access to glucocorticoid receptor. This enzyme is widely expressed not only in liver and adipose tissue, but also in adrenal, ovary and decidua.Western blot analysis in human liver, using a specific11-beta-HSD1 antibody, showed two bands at approximately 34 and 68 kDa confirming the dimeric nature of 11-beta-HSD1 in liver and In omental adipose tissue, an additional band of 50 kDa was strongly expressed.
Images
| Western blot analysis of HSD11B1 (GB111800) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
