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Anti-Heparanase 1 Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Heparanase 1 rabbit polyclonal antibody |
Gene Name: | Heparanase |
Synonyms: | Endo-glucoronidase, Hpse, Hpa, HEP, Heparanase 50 kDa subunit |
Immunogen: | Recombinant protein corresponding to Mouse Heparanase 1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Secreted, Lysosome |
Uniprot ID: | Q71RP1 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Rat | 1: 100-1: 600 | kidney |
Background
Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasations of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and an 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta.
Images
 | Immunohistochemistry of paraffin embedded rat kidney using Heparanase1 (GB112373) at dilution of 1:300 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
