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-23%
Anti-Hsp90 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HSP90 rabbit polyclonal antibody |
Gene Name: | Heat shock protein HSP 90-alpha |
Synonyms: | HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2, HEL-S-65p, Heat shock protein 90kDa alpha |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HSP90A |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 90 kDa |
Observed MW. | 90 kDa |
Uniprot ID: | P07900, P82995, P07901 |
Product Usage Information
Applications | Species | Dilution | Positive Ttissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | colon cancer, brain |
Background
Complemented by the constitutively expressed paralog Hsp90B which shares over 85% amino acid sequence identity, Hsp90A expression is initiated when a cell experiences proteotoxic stress. Once expressed Hsp90A dimers operate as molecular chaperones that bind and fold other proteins into their functional 3-dimensional structures. This molecular chaperoning ability of Hsp90A is driven by a cycle of structural rearrangements fueled by ATP hydrolysis. Current research on Hsp90A focuses in its role as a drug target due to its interaction with a large number of tumor promoting proteins and its role in cellular stress adaptation.
Images
 | Western blot analysis of HSP90 (GB11284-1) at dilution of 1: 500 |
Storage
| Storage | Store at -20 °C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
