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Anti-IPL-1/STK13/Aurora C Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Aurora kinase C |
Synonyms: | Aie1, Aik3, Airk3, Ark3, Stk13, Aurkc, ARK-3, Aurora 3, Aurora/IPL1-related kinase 3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse IPL-1/STK13/Aurora C |
Uniprot ID: | O88445 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Centromere, Chromosome, Cytoplasm, Cytoskeleton, Nucleus |
Product Usage Information
IHC/IF | Mouse | 1: 500-1: 1500 | testis |
Background
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Images
| Immunohistochemistry analysis of paraffin embedded mouse testis using AURKC (GB114842) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
