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Anti-IQGAP1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | IQGAP1 rabbit polyclonal antibody |
Gene Name: | Ras GTPase-activating-like protein IQGAP1 |
Synonyms: | Iqgap1, IQGAP1, HUMORFA01, SAR1, p195, IQ motif containing GTPase activating protein 1, Ras GTPase activating like protein 1 |
Immunogen: | Recombinant protein corresponding to Mouse IQGAP1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cell membrane |
Uniprot ID: | Q9JKF1 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 1500-1: 4000 | brain, cerebral infarction, lung, placenta, spinal cord |
Background
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton such as the formin Dia1 (mDia1), with cell adhesion molecules (CAMs), and with several signaling molecules to regulate cell morphology and motility. For example, IQGAP1 expression is necessary for neuronal process outgrowth on the cell adhesion molecule PTPmu (PTPRM). Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines and its over-expression and distinct membrane localisation is also observed in a range of tumours.
Images
 | Immunohistochemistry of paraffin embedded mouse brain using IQGAP1 (GB11731) at dilution of 1:2000 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse cerebral infarction using IQGAP1 (GB11731) at dilution of 1:2000 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse spinal cord using IQGAP1 (GB11731) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse brain using IQGAP1 (GB11731) at dilution of 1:3000 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse lung using IQGAP1 (GB11731) at dilution of 1:3000 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse placenta using IQGAP1 (GB11731) at dilution of 1:3000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
