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Anti-Integrin alpha 2/CD49b Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Integrin beta-1 |
Synonyms: | Glycoprotein IIa (GPIIA), VLA-4 subunit beta, CD29, ITGB1, FNRB, MDF2, MSK12 |
Immunogen: | Recombinant protein corresponding to Human CD49B |
Uniprot ID: | P05556 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 118 kDa / 130-180kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | A549, A-431, NIH/3T3, T-47D, MCF7, C6 |
Background
Integrins are alpha/beta Heterodimeric somatic cell surface receptors, composed of alpha Subunit and beta It is formed by specific binding of subunits, and the integrin family contains at least 18 alpha And 9 beta Subunits can form 24 integrins with different tissue distribution and ligand specificity. Integrin alpha 2 (ITGA2, also known as CD49b) and integrinbeta 1 formation of heterodimers α2β1, α2β1 As an important adhesion molecule is widely expressed on various cell surfaces and mainly participates in regulating the binding of cells to collagen and cell signal transduction. In normal tissues, ITGA2 is mainly expressed in the skin, lungs, salivary glands, and activated endothelial cells. It is upregulated in various tumors such as gastric cancer, prostate cancer, and non-small cell lung cancer, and is closely related to tumor invasion.
Images
| WB analysis of CD49b (GB115482). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 1000, 4°C overnight. Secondary antibody: HRP Goat Anti-Rabbit lgG (GB23303), 1: 3000, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
