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Anti-Junctional Adhesion Molecule 1/JAM-A Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | JAM-A rabbit polyclonal antibody |
Gene Name: | Junctional adhesion molecule A |
Synonyms: | JAM-A, Junctional adhesion molecule 1, JAM-1, CD321, F11r, Jam1, Jcam, Jcam1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse JAM-A |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 33 kDa |
Observed MW. | 35 kDa |
Uniprot ID: | Q9Y624, O88792, Q9JHY1 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | liver, colon, small intestine |
Background
Seems to play a role in epithelial tight junction formation. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin super family gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as a receptor for reovirus, a ligand for the integrin LFA1, involved in leukocyte transmigration, and a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Images
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Western blot analysis of Junctional adhesion molecule A (GB111062) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
