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Anti-KCNC3 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Potassium voltage-gated channel subfamily C member 3 |
Synonyms: | Kv3.3, SCA13 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human KCNC3 |
Uniprot ID: | Q14003 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cell projection, Cytoplasm, Cytoskeleton |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 300-1: 900 | spinal marrow, cerebellum, brain |
Background
Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics . It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis.
Images
| Immunohistochemistry analysis of paraffin embedded mouse cerebellum using KCNC3 (GB114707) at dilution of 1: 900 |
| Immunohistochemistry analysis of paraffin embedded rat cerebellum using KCNC3 (GB114707) at dilution of 1: 900 |
| Immunohistochemistry analysis of paraffin embedded rat brain using KCNC3 (GB114707) at dilution of 1: 900 |
| Immunohistochemistry analysis of paraffin embedded mouse brain using KCNC3 (GB114707) at dilution of 1: 900 |
| Immunohistochemistry analysis of paraffin embedded rat spinal marrow using KCNC3 (GB114707) at dilution of 1: 900 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
