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Anti-KMT3A / HYPB / HIF-1 Rabbit pAb (100 μl)
| Reactivity: | M & M |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | KMT3A / HYPB / HIF-1 rabbit polyclonal |
Gene Name: | Histone-lysine N-methyltransferase SETD2 |
Synonyms: | HIF-1, HIF1, HIP-1, hSET2, HSPC069, Huntingtin yeast partner B, HYPB, KIAA1732, KMT3A, Lysine N methyltransferase 3A, p231HBP, SET domain containing 2, SET2, SETD2 |
Immunogen: | Recombinant protein corresponding to Mouse KMT3A / HYPB / HIF-1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 286 kDa |
Observed MW. | 286 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse | 1: 300-1: 500 | brain |
IHC | Mouse | 1: 1800-1: 3600 | brain, cerebellum |
Background
SETD2, also named as HIF1, HYPB, KIAA1732, KMT3A, SET2, p231HBP, hSET2 and HIP-1, belongs to the histone-lysine methyltransferase family and SET2 subfamily. SETD2 probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. It binds DNA at promoters. SETD2 may also act as a transcription activator that binds to promoters. It is a potential tumour suppressor gene in breast cancer. This antibody is specific to SETD2.
Images
| Western blot analysis of SETD2 (GB113441) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin-embedded mouse brain using SETD2 (GB113441) at dilution of 1: 3600 |
| Immunohistochemistry analysis of paraffin-embedded mouse cerebellum using SETD2 (GB113441) at dilution of 1: 3600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
