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Anti-KMT3C/SMYD2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | KMT3C/SMYD2 rabbit polyclonal antibody |
Gene Name: | N-lysine methyltransferase SMYD2 |
Synonyms: | Histone methyltransferase SMYD2, SET and MYND domain-containing protein 2, Smyd2, Lysine N-methyltransferase 3C, MGC119305, N lysine methyltransferase SMYD2 |
Immunogen: | Recombinant protein corresponding to Mouse SMYD2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: | Q8R5A0, Q7M6Z3 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 1000-1: 4000 | Bone fibroids, brain, heart, Skeletal muscle |
Background
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53.
Images
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Immunohistochemistry of paraffin embedded mouse heart using SMYD2 (GB111583) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse brain using SMYD2 (GB111583) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse Skeletal muscle using SMYD2 (GB111583) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded rat Bone fibroids using SMYD2 (GB111583) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded rat heart using SMYD2 (GB111583) at dilution of 1:2000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
