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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | KSR1 rabbit polyclonal antibody |
Gene Name: | Kinase suppressor of Ras 1 |
Synonyms: | mKSR1, Protein Hb, Ksr1, Ksr, BKSR1, EK31, RSU2, SR31, Suppressor of Ras1 31 |
Immunogen: | Recombinant protein corresponding to Mouse KSR1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 97 kDa |
Observed MW. | 97 kDa |
Uniprot ID: | Q61097 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | brain |
Background
KSR1 is a molecular scaffold and positive regulator of the Raf/MEK/ERK phosphorylation cascade. It was initially considered to be a protein kinase acting in the Ras pathway. KSR1 is required for maximal ERK activation induced by growth factors and by some cytotoxic agents. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane associated.
Images
| Western blot analysis of KSR1 (GB111949) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
