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Anti-Kaptin Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | KICSTOR complex protein kaptin |
Synonyms: | 2E4, Actin associated protein 2E4, Kaptin, kaptin (actin binding protein), KPTN |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Kaptin |
Uniprot ID: | Q8VCX6 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 48 kDa / 50 kDa |
Product Usage Information
WB | Mouse | 1: 2000-1: 4000 | skeletal muscle, brain |
Background
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Images
| Western blot analysis of KPTN (GB115187) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
