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Anti-L1CAM Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | L1CAM rabbit polyclonal |
Gene Name: | Neural cell adhesion molecule L1 |
Synonyms: | N-CAM-L1, CD171, L1cam, Caml1, L1-NCAM, MASA, MIC5, NILE, SPG1, HSAS1, Hyd |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse L1CAM |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 141 kDa |
Observed MW. | 140/220 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, hippocampus, cortex, cerebellum |
IHC | Mouse, Rat | 1: 400-1: 800 | brain, embryonic brain, substantia nigra |
Background
L1cam (L1 cell adhesion molecule isoform 1 precursor) is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus).
Images
| Western blot analysis of L1CAM (GB112046) at dilution of 1: 1000 Lane 1: Mouse brain tissue lysate Lane 2: Mouse hippocampus tissue lysate Lane 3: Rat brain tissue lysate Lane 4: Rat hippocampus tissue lysate |
| Western blot analysis of L1CAM (GB112046) at dilution of 1: 1000 Lane 1: Mouse brain tissue lysate Lane 2: Mouse cortex tissue lysate Lane 3: Mouse hippocampus tissue lysate Lane 4: Mouse cerebellum tissue lysate Lane 5: Rat brain tissue lysate Lane 6: Rat cortex tissue lysate Lane 7: Rat hippocampus tissue lysate |
| Immunohistochemistry analysis of paraffin-embedded mouse brain using L1CAM (GB112046) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin-embedded mouse embryonic brain using L1CAM (GB112046) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin-embedded fetal mouse brain using L1CAM (GB112046) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin-embedded rat substantia nigra using L1CAM (GB112046) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
