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Anti-LDL Receptor Rabbit pAb (100 μl)
| Reactivity: | M & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | LDL Receptor rabbit polyclonal |
Gene Name: | Low-density lipoprotein receptor |
Synonyms: | LDLR, FH, FHC, LDLCQ2, low density lipoprotein receptor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LDL Receptor |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Endomembrane system |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 200-1: 1000 | lymphoma, thymus, liver, spleen |
IF | Human, Mouse, Rat | 1: 200-1: 1000 | lymphoma, thymus, liver, spleen |
Background
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins . Acts as a receptor for vesicular stomatitis virus. In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Images
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Immunohistochemistry analysis of paraffin-embedded human Lymphoma using LDL Receptor (GB11369) at dilution of 1:500. |
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Immunohistochemistry analysis of paraffin-embedded mouse thymus using LDL Receptor (GB11369) at dilution of 1:500. |
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Immunohistochemistry analysis of paraffin-embedded rat liver using LDL Receptor (GB11369) at dilution of 1:500. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
