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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Leucine-rich repeat-containing G-protein coupled receptor 5 |
Synonyms: | G-protein coupled receptor 49, Orphan G-protein coupled receptor FEX, Lgr5, Gpr49, FEX, HG38 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LGR5 |
Uniprot ID: | Q9Z1P4 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 100 kDa / 110 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 500 | brain, testis |
Background
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Images
| WB analysis of lgr5 (GB115533). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
