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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | LIFR rabbit polyclonal |
Gene Name: | Leukemia inhibitory factor receptor |
Synonyms: | LIF receptor, LIF-R, D-factor/LIF receptor, CD118, Lifr, SJS2, STWS, LIF-R, LIFR |
Immunogen: | Recombinant protein corresponding to Mouse LIFR |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 123 kDa |
Observed MW. | 190 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | heart, liver, kidney, placenta |
Background
LIFR, also known as CD118 is a subunit of a receptor for leukemia inhibitory factor (LIF). LIF is a pleiotropic cytokine of the interleukin-6 family which affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIFR is the low-affinity binding chain that, together with the high-affinity converter subunit gp130, forms a high-affinity receptor complex that mediates the action of LIF. The high-affinity complex also binds a related cytokine, oncostatin M. LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway.
Images
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Western blot analysis of LIFR (GB111476) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
