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Anti-LYNX1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ly-6/neurotoxin-like protein 1 |
Synonyms: | Ly6/neurotoxin 1, LYNX1, SLURP 2, SLURP2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LYNX1 |
Uniprot ID: | P0DP60 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cell projection |
Predicted MW. / Observed MW. | 13 kDa / 15 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, kidney, thymus |
IHC/IF | Rat | 1: 500-1: 1500 | brain |
Background
Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) . The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs . Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum.
Images
| Western blot analysis of LYNX1 (GB115263) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat brain using LYNX1 (GB115263) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
