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Anti-LYVE1 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | LYVE1 rabbit polyclonal antibody |
Gene Name: | Lymphatic vessel endothelial hyaluronic acid receptor 1 |
Synonyms: | LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor, CRSBP1, HAR, XLKD1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LYVE1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Uniprot ID: | Q9Y5Y7 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1: 100-1: 800 | colon, small intestine, tonsil |
Background
LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Images
| Immunohistochemistry of paraffin embedded human colon using lyve-1 (GB111689) at dilution of 1:400 (400x lens) |
| Immunohistochemistry of paraffin embedded human small intestine using lyve-1 (GB111689) at dilution of 1:400 (400x lens) |
| Immunohistochemistry of paraffin embedded human tonsil using lyve-1 (GB111689) at dilution of 1:400 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
