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Anti-Leptin Receptor Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Leptin Receptor rabbit polyclonal antibody |
Gene Name: | Leptin receptor |
Synonyms: | LEP-R, B219, OB receptor, OB-R, CD295, LEPR, Db, Obr, LEPRD |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Leptin Receptor |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Secreted |
Predicted MW. | 131 kDa |
Observed MW. | 131 kDa |
Uniprot ID: | P48357, P48356, Q62959 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 250-1: 500 | brain, lung, ovary, kidney |
IHC/IF | Mouse, Rat | 1: 500-1: 1000 | hippocampus, substantia nigra |
Background
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction.
Images
 | Western blot analysis of LeptinReceptor (GB112091) at dilution of 1: 250 |
 | Immunofluorescence of paraffin embedded mouse substantia nigra using LR (GB112091) at dilution of 1: 500 (300x lens) |
| Immunofluorescence of paraffin embedded rat hippocampus using LR (GB112091) at dilution of 1: 500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
