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Anti-Lin28A Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Lin28A rabbit polyclonal antibody |
Gene Name: | Protein lin-28 homolog A |
Synonyms: | Lin-28A, Testis-expressed protein 17, Lin28a, Lin28, Tex17 |
Immunogen: | Recombinant protein corresponding to Mouse Lin28A |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 23 kDa |
Observed MW. | 28 kDa |
Uniprot ID: | Q8K3Y3 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | liver, skeletal muscle, testis |
Background
LIN28A/B are expressed in various cancers and ES cells. LIN28 is a cytoplasmic protein, that acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. LIN28 is a negative regulator of microRNA (miRNA) biogenesis by specifically binding the precursor of let-7 (pre-let-7). Let-7 miRNAs have been implicated in repression of oncogenes such as ras and myc. LIN28 expression decreases during differentiation of ES cells or upon induction of neuronal differentiation by retinoic acid.
Images
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Western blot analysis of Lin28A (GB111416) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
