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Anti-MAG/GMA Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MAG/GMA rabbit polyclonal antibody |
Gene Name: | Myelin-associated glycoprotein |
Synonyms: | Siglec-4a, Mag, GMA, S-MAG, SIGLEC4A, SPG75, Sialic acid binding Ig like lectin 4A |
Immunogen: | Recombinant protein corresponding to Mouse MAG |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. | 69 kDa |
Observed MW. | 100 kDa |
Uniprot ID: | P20917, P07722 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 1000-1: 2000 | brain, cortex, cerebellum, spinal cord |
IHC/IF | Mouse, Rat | 1: 300-1: 1200 | brain |
Background
MAG (myelin associated glycoprotein) is a Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha2,3-linked sialic acid. Isoform L-MAG is critical for the formation of myelin in the CNS, whereas isoform S-MAG is sufficient to maintain the integrity of myelin in PNS. Binds to RTN4R. Isoform S-MAG is the predominant isoform in CNS and PNS of the adult. In CNS isoform L-MAG is the major form synthesized early in development, and it persists as a significant proportion of the MAG present in the adult.
Images
| Western blot analysis of MAG (GB112158) at dilution of 1: 1000 |
| Immunohistochemistry of paraffin embedded mouse brain using MAG (GB112158) at dilution of 1: 600 (300x lens) |
 | Immunohistochemistry of paraffin embedded rat brain using MAG (GB112158) at dilution of 1: 600 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
