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| Reactivity: | H,M & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MAL2 rabbit polyclonal antibody |
Gene Name: | Protein MAL2 |
Synonyms: | Mal2, MAL proteolipid protein 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MAL2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. | 19 kDa |
Observed MW. | 30 kDa |
Uniprot ID: | Q969L2, Q8BI08 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 1000 | kidney |
IHC/IF | Mouse, Rat | 1: 300-1: 1600 | duodenum, kidney, liver, lung |
Background
MAL2 (mal, T-cell differentiation protein 2) is a 176 amino acid multi-pass membrane protein that is associated with lipid rafts and contains one MARVEL domain. Expressed predominately in liver, kidney and lung, MAL2 functions as a member of the polarized machinery transport system and is required for transcytosis, a transporter pathway used to deliver membrane-bound cargo from perinuclear endosomes to the apical surface in a raft-dependent manner. Differential expression of MAL2 is associated with several cancers, including renal cell carcinoma and childhood leukemia, suggesting a role for MAL2 in tumorigensis.
Images
| Western blot analysis of MAL2 (GB112255) at dilution of 1: 500 |
| Immunohistochemistry of paraffin embedded mouse duodenum using MAL2 (GB112255) at dilution of 1: 700 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse kidney using MAL2 (GB112255) at dilution of 1: 700 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse liver using MAL2 (GB112255) at dilution of 1: 700 (400x lens) |
| Immunohistochemistry of paraffin embedded rat kidney using MAL2 (GB112255) at dilution of 1: 700 (400x lens) |
| Immunohistochemistry of paraffin embedded rat liver using MAL2 (GB112255) at dilution of 1: 700 (400x lens) |
| Immunohistochemistry of paraffin embedded rat lung using MAL2 (GB112255) at dilution of 1: 300 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse kidney using MAL2 (GB112255) at dilution of 1: 650 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse lung using MAL2 (GB112255) at dilution of 1: 650 (400x lens) |
| Immunofluorescence of paraffin embedded rat kidney using MAL2 (GB112255) at dilution of 1: 650 (400x lens) |
| Immunofluorescence of paraffin embedded rat lung using MAL2 (GB112255) at dilution of 1: 650 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
