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Anti-MAP3K12 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MAP3K12 rabbit polyclonal |
Gene Name: | Mitogen-activated protein kinase kinase kinase 12 |
Synonyms: | Dual leucine zipper bearing kinase, Leucine-zipper protein kinase, DLK, ZPK, MAPK-upstream kinase, MUK, Mixed lineage kinase, Map3k12 |
Immunogen: | Recombinant protein corresponding to Mouse MAP3K12 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 200-1: 400 | kidney |
Background
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
Images
 | Immunohistochemistry analysis of paraffin-embedded human kidney using MAP3K12 (GB113489) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
