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Anti-MCK10/NEP Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MCK10 rabbit polyclonal antibody |
Gene Name: | Epithelial discoidin domain-containing receptor 1 |
Synonyms: | Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, CAK, EDDR1, NEP, NTRK4, PTK3A, MCK-10, CD167a, DDR1, RTK6, TRKE |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human MCK10 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Secreted |
Uniprot ID: | Q08345 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1:400-1:1000 | colon, colon cancer, esophagus, ovarian cancer |
Background
This protein belongs to a subfamily of tyrosine kinase receptors. The Tyrosine kinase functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases.
Images
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Immunohistochemistry of paraffin embedded human colon using DDR1 (GB111290) at dilution of 1:450 (400x lens) |
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Immunohistochemistry of paraffin embedded human colon cancer using DDR1 (GB111290) at dilution of 1:450 (400x lens) |
| Immunofluorescence of paraffin embedded human colon cancer using DDR1 (GB111290) at dilution of 1:400 (400x lens) |
| Immunofluorescence of paraffin embedded human esophagus using DDR1 (GB111290) at dilution of 1:400 (400x lens) |
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Immunofluorescence of paraffin embedded human ovarian cancer using DDR1 (GB111290) at dilution of 1:400 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
