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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MCU rabbit polyclonal antibody |
Gene Name: | Calcium uniporter protein, mitochondrial |
Synonyms: | HsMCU, Coiled-coil domain-containing protein 109A, MCU, C10orf42, CCDC109A |
Immunogen: | Recombinant protein corresponding to Mouse MCU |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 40 kDa |
Observed MW. | 30-35 kDa |
Uniprot ID: | Q8NE86, Q3UMR5 |
Applications
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 800 | PANC-1, A549, NIH/3T3 |
Background
MCU, also known as CCDC109A, is a mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) . The MCU protein is composed of two coiled-coil domains, two TMDs, and a short motif of amino acids between the two TMDs. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.
Images
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Western blot analysis of MCU (GB111353) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
