Anti-MDA5 Rabbit pAb (100 μl)

Anti-MDA5 Rabbit pAb (100 μl)

Brand: ServiceBio
Cat. #: GB111891-100
Availability: In Stock
$259.00
-+
Reactivity: M    
Applications: IHC/IF    
Host Species: Rabbit    
Clonality: Polyclonal    
Full Name:

MDA5 rabbit polyclonal

Gene Name:

Interferon-induced helicase C domain-containing protein 1

Synonyms:

Helicase with 2 CARD domains, Helicard, Melanoma differentiation-associated protein 5, MDA-5, RIG-I-like receptor 2, RLR-2, Ifih1, RH116, MDA5

Immunogen:

KLH conjugated Synthetic peptide

corresponding to Mouse MDA5

Isotype:

IgG

Purity:

Affinity purification

Subcellular location:

Cytoplasm, Nucleus

Uniprot ID:

Q8R5F7




Product Usage Information

IHC/IF

Mouse

1: 300-1: 600

heart, kidney, liver




Background

IFIH1 (Interferon-induced helicase C domain-containing protein 1) is a putative RNA helicase that is upregulated in response to treatment with IFNB or IFNB and MEZ. It is also named as MDA5 and RH116. Ectopic expression of MDA5 in melanoma cells resulted in reduced colony formation, suggesting an interaction of the CARD and apoptotic signal molecules. Functional analysis indicated that MDA5 is an RNA-dependent ATPase. IFIH1 has an apparent molecular mass of 117-130 kDa, and always other bands (70 kDa and 90 kDa) can be detected as cleaved products.




Images

Immunohistochemistry analysis of paraffin-embedded mouse liver using

MDA5 (GB111891) at dilution of 1: 600

Immunohistochemistry analysis of paraffin-embedded mouse kidney using

MDA5 (GB111891) at dilution of 1: 600

Immunohistochemistry analysis of paraffin-embedded mouse heart using

MDA5 (GB111891) at dilution of 1: 600

Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using

MDA5 (GB111891) at dilution of 1: 600

Immunofluorescent analysis of paraformaldehyde-fixed mouse kidney longitudinal using 

MDA5 (GB111891) at dilution of 1: 600




Storage

StorageStore at -20°C for one year. Avoid repeated freeze/thaw cycles.
Storage BufferPBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


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