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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Tripartite motif-containing protein 72 |
Synonyms: | hMG53, Mg53, Mitsugumin 53, TRIM72, tripartite motif containing 72 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MG53 |
Uniprot ID: | Q1XH17 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 53 kDa / 53 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 800 | skeletal muscle |
Background
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation.
Images
| Western blot analysis of TRIM72 (GB114578) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
