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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Dual specificity mitogen-activated protein kinase kinase 6 |
Synonyms: | MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, MEK 6, SAPKK3, Map2k6, Prkmk6, MAPKK6 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MKK6 |
Uniprot ID: | P70236 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 37 kDa / 37 kDa |
Product Usage Information
WB | Human, Mouse | 1: 300-1: 600 | cerebellum, muscle |
Background
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1.
Images
| WB analysis of MAP2K6 (GB115515). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
