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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MLH1 rabbit polyclonal antibody |
Gene Name: | DNA mismatch repair protein Mlh1 |
Synonyms: | MutL protein homolog 1, COCA2, FCC2, hMLH1, HNPCC, HNPCC2, MLH1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MLH1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Chromosome, Nucleus |
Uniprot ID: | Q9JK91, P97679 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 400-1: 1000 | COLON, heart, lung, prostate, spleen, testis |
Background
MLH1, also named as COCA2, belongs to the DNA mismatch repair mutL/hexB family. It heterodimerizes with PMS2 to form MutL alpha which is a component of the post-replicative DNA mismatch repair system (MMR). MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. MLH1 also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.
Images
| Immunohistochemistry of paraffin embedded mouse heart using MLH1 (GB111957) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse lung using MLH1 (GB111957) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse testis using MLH1 (GB111957) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat COLON using MLH1 (GB111957) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat heart using MLH1 (GB111957) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat lung using MLH1 (GB111957) at dilution of 1:500 (400x lens) |
| Immunofluorescence of paraffin embedded human prostate using MLH1 (GB111957) at dilution of 1:500 (400x lens) |
| Immunofluorescence of paraffin embedded mouse lung using MLH1 (GB111957) at dilution of 1:500 (400x lens) |
 | Immunofluorescence of paraffin embedded rat heart using MLH1 (GB111957) at dilution of 1:500 (400x lens) |
| Immunofluorescence of paraffin embedded rat spleen using MLH1 (GB111957) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
