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Anti-MRAP2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Melanocortin-2 receptor accessory protein 2 |
Synonyms: | C6orf117, MRAP2, RP11 51G5.2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MRAP2 |
Uniprot ID: | D3Z1Q2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 24 kDa / 24 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 800 | kidney |
Background
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo.
Images
| Western blot analysis of MRAP2 (GB114595) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
