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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Mortality factor 4-like protein 2 |
Synonyms: | IAA0026, MORF related gene X protein, MORF4L2, MORFL2, mortality factor 4 like 2, MRGX, Protein MSL3 2 |
Immunogen: | Recombinant protein corresponding to Mouse MRGX |
Uniprot ID: | Q9R0Q4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 32 kDa / 30 kDa |
Product Usage Information
WB | Mouse | 1: 3000- 1: 6000 | liver |
Background
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).
Images
| Western blot analysis of MORF4L2 (GB114182) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
